PI & CMI Trade Names and Active Ingredients containing doxorubicin. 7 Documents available Doxorubicin Ebewe, PI, Doxorubicin hydrochloride. Doxorubicin. Doxil official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Find information on drug affordability programs for DOXIL® (doxorubicin HCl liposome injection). Learn how patients who have been.
|Published (Last):||1 August 2015|
|PDF File Size:||10.9 Mb|
|ePub File Size:||3.37 Mb|
|Price:||Free* [*Free Regsitration Required]|
A hazard ratio less than 1 indicates an advantage for Doxil. Erythema, desquamation, or swelling interfering with, but not precluding normal physical activities; small blisters or ulcerations less than 2 cm in diameter.
The following additional adverse reactions were observed in patients with AIDS-related Kaposi’s sarcoma. This information is intended for the use of patients and caregivers in the United States and Puerto Rico only. For neuropathic pain or peripheral neuropathy, no dosage adjustments are required for Doxil.
Serious, life-threatening and fatal infusion reactions have been reported [see Dosage and Administration 2. Doxorubicinol, the major metabolite of doxorubicin, was detected at concentrations of 0.
Assess left ventricular cardiac function e. Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician. Because clinical trials are conducted under widely dosil conditions, the adverse reaction rates observed cannot be directly compared to rates on other clinical trials and may not reflect the rates observed in clinical practice.
IMPORTANT SAFETY INFORMATION
However, in some cases, these reactions may be serious and sometimes life-threatening and may be fatal. Are there any special precautions patients should be aware of before starting treatment?
The background risk of major birth defects and miscarriage for the indicated populations are unknown. In addition, if liposomal doxorubicin escapes from the vein in which it is being administered, it can cause damage to tissues it comes in contact with.
FDA alerts for all medications.
I have no coverage View all programs. Tell your doctor if you experience these or other side effects. The safety and effectiveness of Doxil in pediatric patients have not been established. Independent co-pay assistance foundations Independent co-pay assistance foundations have their own rules for eligibility.
Los Angeles Cancer Network Doxil® – Los Angeles Cancer Network
Manage confirmed or suspected extravasation as follows:. Subscribe to free Drugs. Respiratory, Thoracic and Mediastinal Disorders: Your healthcare provider will temporarily stop the infusion to control the symptoms and resume treatment at a reduced rate.
No, I am not. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician. Many states have programs for people with limited income and resources that pay some or all of Medicare’s premiums and may pay Medicare deductibles and co-insurance.
TTP was defined as the time from randomization to the first occurrence of progressive disease or death due to progressive disease. Results are provided in Table Erythema, desquamation, or swelling interfering with, but not precluding normal physical activities; small blisters or ulcerations less than 2 cm in diameter Delay dosing up to 2 weeks or until resolved to Grade 0—1.
We want to guide you to programs that may help. Patients should ask their physician for recommended products for this use. How is liposomal doxorubicin given administered? The ultimate responsibility for patient care resides with a healthcare professional.
The plasma clearance of total doxorubicin from Doxil was 0. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy. Medicare Savings Program Many states have programs for people with limited income and resources that pay some or all of Medicare’s premiums and may pay Medicare deductibles and co-insurance. In certain cases, this reaction can be more severe leading to serious infections, interfering with walking and other daily activities.
We cannot guarantee a foundation will help you. It is not known whether Doxil is present in human milk. At the current time, patient affordability programs for the selected insurance option are not available for this product. Patients who maintained a response were allowed to receive further treatment.
The following additional adverse reactions have been identified during post approval use of Doxil. The pharmacokinetic parameters for total roxil following a single dose of Doxil odxil over 30 minutes are presented in Table 8. Liposomal doxorubicin belongs to a group of agents called anthracycline antitumor antibiotics. If no infusion-related adverse reactions are observed, increase the infusion rate to complete the administration of the drug over one hour [see Warnings and Precautions 5.
Mild erythema, swelling, or desquamation not interfering with daily activities If no previous Grade 3 or 4 HFS: Call the programs or visit their websites to learn more.
Blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the kidneys or pk. If after 2 weeks there is no resolution, discontinue Doxil.
This may lead to tingling or burning, redness, flaking, bothersome swelling, small blisters, or small sores on palms of hands or soles of feet.