Neonatal seizures or neonatal convulsions are epileptic fits occurring from birth to the end of the neonatal period. The neonatal period is the most vulnerable of. Neonatal Seizures. DEFINITION: A Neonatal seizures are the most common overt manifestation of neurological Benign Familial Neonatal Convulsions. Neonatal seizures can be difficult to diagnose because the seizure may be short and subtle. In addition, symptoms of neonatal seizures may mimic normal.

Author: Kazralabar Doujora
Country: Liechtenstein
Language: English (Spanish)
Genre: Finance
Published (Last): 1 March 2010
Pages: 298
PDF File Size: 6.48 Mb
ePub File Size: 3.51 Mb
ISBN: 166-1-94631-925-1
Downloads: 44490
Price: Free* [*Free Regsitration Required]
Uploader: Akinojin

Ohtahara syndrome manifests with clinico- EEG features of mainly tonic spasms and suppression—burst EEG patterns that consistently occur in the sleeping and waking states. Jitteriness or tremulousness of the extremities or facial muscles is frequent in normal or abnormal neonates.

Neonatal seizures of metabolic disturbances need correction of the underlying cause and not anti-epileptic medication. Chapter 5 Neonatal Seizures and Neonatal Syndromes. The age at onset is characteristically between the first and seventh days of life. The incidence of seizures is higher in the neonatal period than at any other time of life, [3] and most often occurs in the first week of life.

Unsourced material may be challenged and removed. The patterns may be synchronous or asynchronous, focal or multifocal and, less frequently, generalised.

Neonatal seizure – Wikipedia

All seizures started with tonic motor activity and posturing with apnoea for 5—10 s followed by vocalisations, ocular symptoms, other autonomic features, motor automatisms, chewing and focal or generalised, asymmetrical, occasionally unilateral clonic movements. Early-infantile epileptic encephalopathy with suppression-bursts, Ohtahara syndrome; its overview referring to our 16 cases. Gaze deviation or eye movements do not occur.

Electrical seizures may be highly resistant to drug treatment and attempts to eliminate them may require high doses of usually multiple drugs with significant adverse reactions such as CNS or respiratory depression and systemic nonatalf. Familial neonatal and infantile seizures: Hyperekplexia phenotype due to compound heterozygosity for GLRA1 gene mutations.


Neonatal seizure

Non-Epileptic Neonatal Seizures Many of the subtle seizures, generalised tonic posturing and some myoclonic symptoms may be non-epileptic seizures. This is supported by onnatale fact that, between 2 and convulskon months of age, the clinico- EEG features often change to those of West syndrome and later to Lennox—Gastaut syndrome.

This should include serum levels of amino acids and particularly glycine and glycerol metabolites, organic acids and amino acids in the cerebrospinal fluid. There is an age-related evolution of clinical and EEG patterns from Ohtahara syndrome, first to West syndrome and then to Lennox—Gastaut syndrome.

Proposal for revised classification of epilepsies and epileptic syndromes. These are the same as those for neonatal seizures, attempting to find an aetiological cause. Benign neonatal sleep myoclonus should be easy to convullsion from relevant epileptic disorders in this age group by its occurrence in normal neonates and only during sleep. The prevalence of mental retardation and learning disability is reported to be approximately 2.

Stimulation can provoke myoclonic seizures. Partial seizures may occur. Diagnostic tips for benign neonatal seizures non-familial A single episode of repetitive clonic seizures that are mainly unilateral, often of alternating side and lasting for around 20 h in a full-term neonate that was normal up to that stage.

Etiology of convulsions in neonatal and infantile period.

Aetiology The most common cause is malformations of cerebral development such as hemimegalencephaly, porencephaly, Aicardi syndrome, olivary-dentate dysplasia, agenesis of mamillary bodies, linear sebaceous naevus syndrome, cerebral dysgenesis and focal cortical dysplasia.

Primidonevalproatelignocaine68 carbamazepine 69 and paraldehyde now not available in the USA are also used mainly as adjunctive AEDs if others fail. Clinical and neurophysiologic correlates of neonatal seizures; pp.

Lidocaine treatment of neonatal convulsions, a therapeutic dilemma. Tonic seizures manifest with sustained contraction of facial, limb, axial and other muscles. Ital J Neurol Sci. Benign neonatal sleep myoclonus. Non-Epileptic Movement Disorders Neonatal seizures should be differentiated from nonxtale neonatal sleep myoclonus, hyperekplexia and other non-epileptic movement disorders.


Generalized tonic seizures mimic decorticate posturing; the majority are not associated with electrographic seizures. They are described as subtle because the clinical manifestations are frequently overlooked. Arbor Publishing Corp; Brain Imaging Cranial ultrasonography, brain imaging with X-ray computed tomography CT scan and preferably cinvulsion resonance imaging MRI 37 should be used for the detection of structural abnormalities such as malformations of cortical development, intracranial haemorrhage, hydrocephalus and cerebral infarction.

The clinical conundrum of neonatal seizures. The post-ictal state is brief and inter-ictally the neonates are normal. Pathophysiology The pathophysiology is unknown. Myoclonic seizures are associated with the most severe brain damage. They may appear and disappear suddenly or build up from accelerating localised repetitive waves. Apnoea is convilsion common concomitant in one-third of these clonic fits.

The Burst—suppression Pattern in Ohtahara Syndrome versus Early Myoclonic Encephalopathy There are certain differentiating features of burst—suppression pattern between Ohtahara syndrome and early myoclonic encephalopathy. The interval between the onsets of two successive bursts is in the range of 5—10 s. The term erratic is because the myoclonias shift typically from one part of the body to another in a random and asynchronous fashion. Benign non-familial neonatal seizures versus benign familial neonatal seizures.

They may be generalised and symmetrical or lateralised. According to Ohtahara the suppression—burst pattern of early myoclonic encephalopathy is accentuated during sleep and often may not occur in the awake state while this is continuous in Ohtahara syndrome. Early-infantile epileptic encephalopathy with suppression-bursts.